Movement Disorders
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Winter 1998-1999
Volume 9, Number 2
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 Contents of this Issue
From the Guest Editor
Christopher F. O’Brien, MD
Movement and Function: Current
Understanding and Care
Christopher F. O’Brien, MD
New understanding of pathophysiology, genetics, and diagnostic tools have led
to more effective therapies and, indeed, a marked
increase in clinical and research activities at the CNI
Movement Disorders Center. With this growth, and the
addition of personnel to the program, we are optimistic
about the future for patients seeking help for
Parkinsons’ Disease, tremor, dystonia, and other
movement disorders.
Neuroimaging of Movement Disorders
Erin C. Prenger, DO
Neuroimaging can provide useful
information for the evaluation and monitoring of patients
with movement disorders. The distribution of trace
paramagnetic substances - particularly iron - with the
extrapyramidal system can be accurately assessed with
magnetic resonance imaging (MRI). Abnormalities of iron
distribution can provide keys to aid in differential
diagnosis. Neuroimaging also plays an important role in
excluding other central nervous system pathology, which
may mimic the more common causes of movement disorders.
Huntington’s Disease
Lauren C. Seeberger, MD
Huntington’s Disease (HD) is an
important neurodegenerative disease by virtue of its
genetic inheritance, clinical manifestations, and
devastating impact on families. The biological basis,
differential diagnosis, and treatment is reviewed
in-depth. Care for patients, specialized genetic testing
protocols, and opportunities for enrollment in clinical
research trials are offered as part of the CNI Movement
Disorders Center.
Clinical Research Trials: The Future
Looks Bright
Colleen K. Dingmann, RN, MS
The number of clinical research
trials being conducted has tripled over the last 10
years, and the trend looks to continue, particularly in
the field of neuroscience. There is no better time to
consider participating in these trials. This article will
address future developments, different phases, and the
steps to carry out clinical research trials.
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