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What's New
Colorado Neurological Institute (CNI)
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Research Study RecruitmentPatients willing to participate in research studies are needed in the areas of Huntington's Disease and Stroke. CNI is currently recruiting Research Subjects for the following studies:
For more information about these studies or other studies being conducted at CNI please e-mail Sherrie Montallano at Montellano@megapathdsl.net ** Huntington's Disease **PREDICT-HD Neurobiological Predictors of Huntington's DiseasePREDICT-HD is studying people at risk for Huntington's Disease to determine
We hope that this study will provide some essential information for future trials of experimental drugs for HD. It is necessary to get information on the early stages of HD in order to develop drugs that can slow or postpone the onset of HD. Many families reported that drugs to slow the disease may be more meaningful for at-risk persons. This is, slowing the disease is important to do when a person can remain active in work, parenting and enjoying life (rather than in late stages of the disease). To date, little research has been done on individuals who are at risk for developing an inherited disease. WE hope this study will help us to detect the earliest signs of HD so that future drug studies can target treatment that may slow the progression of or prevent HD. Who is eligible to participate? Individuals who:
PREDICT is an observational study. Patients are seen on a yearly basis. Blood samples are taken at the beginning of the study. Everything is kept confidential. During the study, patients are asked to get an MRI scan every 2 years. Comprehensive cognitive testing is also done at each visit. Study duration for PREDICT is about 4 years. What if I do not want anyone to know I am at risk for HD? How will my privacy be detected? Privacy is a central concern in PREDICT-HD, and we have designed the study to protect the confidentiality of research participants to the fullest extent possible. Names will not appear on the study forms -- instead, a code number will be assigned to identify participants. A code (different from the participant code) will be used to identify blood samples and DNA results. I want to help HD research, but would prefer not to learn whether I am developing signs of HD. Is it possible to still participate? Yes. Participants will not be told if they are developing signs of HD. If participants decide they do wish to know this information, they will need to arrange for an evaluation outside of the PREDICT-HD study visits. Are there any risks to me as a participant in PREDICT-HD? Uncertainties of now knowing when HD will start may cause distress. There are some minor risks when blood in drawn for the blood sample. These risks are further explained in the consent form, and the research investigator can answer any questions. What is the benefit to me of participating in PREDICT-HD? There is no direct health benefit from participating in PREDICT-HD. However, participation may help to provide important information useful for understanding the onset of HD in persons at risk for the illness. Who is conducting this study? The Colorado Neurological Institute (CNI) is one of the participating sites for the PREDICT-HD study. The study is conducted by the Huntington Study Group (HSG), an international consortium of more than 200 clinical investigators, coordinators, scientists and staff from 55 participating hospitals and universities in North American, Europe and Australia. If you are interested in participating
in this study, please contact ** Huntington's Disease **PHAROS (Pilot Huntington At Risk Observational Study)The PHAROS project is an observational study in North America (US and Canada) of people ages 30-54 who are at risk for Huntington's disease. The Huntington's Study Group is sponsoring it. To date, there is little research on people at risk for developing an inherited disease (such as the children of a parent with Huntington's disease). We hope this study will help us to answer some important questions, such as:
We hope that this study may provide some essential information for future trials of experimental drugs for HD. Who is eligible to participate in PHAROS?
During the study, subjects will be evaluated every nine (9) months for a period of three years using a survey known as the Unified Huntington's Disease Rating Scale (UHDRS), which looks at movement, psychological and behavioral functioning. A blood sample will also be taken at the beginning of the study, and will be confidentially tested to determine if the participant has the gene for HD. Neither the participant nor any of the physicians or coordinators of PHAROS will ever learn the results of individual gene testing. If you are interested in participating
in this study, please contact ** Stroke **EVEREST. To study effects of cortical stimulation plus rehabilitation therapy to rehabilitation therapy alone.As the first JCAHO-certified Stroke Center and the only Comprehensive Stroke Center in Colorado, Swedish Medical Center and physicians at the Colorado Neurological Institute (CNI) have been approved to participate in a pivotal clinical study to evaluate the safety and effectiveness of investigational (cortical stimulation) therapy for recovery of hand/arm function in survivors of stroke. The study, known as EVEREST, is a randomized, multi-center study comparing the effects of cortical stimulation plus rehabilitation therapy to rehabilitation therapy alone. Cortical stimulation therapy involves the precise delivery of low levels of electricity to the surface of the brain via an implanted stimulator system. The EVEREST study focuses on people age 21 years or older who have had an ischemic stroke at least four months prior to screening and suffered resulting weakness in one hand and/or arm. Stroke patients who would like to receive more information or enroll in the trial should contact the EVEREST study call center at 888-546-9779. For more information about these studies or other studies being conducted at CNI please e-mail us |
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