Parkinson’s Disease Studies

If you think you may qualify for one of these studies, please contact CNI’s Research Department at 303-806-7423.

Brain signal recording for a Smart DBS system: We want to know what you’re thinking! New recording Deep Brain Stimulation (DBS) technology is able to sense your brain signals and predict what you are planning to do. Parkinson’s disease is dynamic. Symptoms change from moment to moment, but current DBS therapy is only adjusted in the doctor’s office. Predictive, Smart DBS will be able to adjust stimulation to your personal goals and activities. If you have Parkinson’s disease, you may be eligible for this study. Eligible participants will receive the Medtronic Activa® PC+S, a new investigational device that records brain waves as well as provides proven DBS therapy. If you choose to participate, we will record your brain signals while performing simple tasks such as walking, moving your arms, and reciting words. We strive to understand how these brain signals control behaviors to develop the next generation of DBS systems that can dynamically adjust to your goals. Help us develop smart DBS systems for Parkinson’s disease.
Principal Investigator: Adam Hebb, MD, FRCSC

Developing a Smart DBS: Deciphering Brain Networks for Adaptable Stimulation: The human brain is an incredibly complex system of electrical neurons and pathways. How the brain orchestrates human behavior such as speaking and decision making, functions that are impaired by neurological disease, is poorly understood. We are currently enrolling adults who are considering DBS surgery in a study of human brain activity. Participants will be asked to perform motor, speech, and decision making tasks during surgery when brain activity is recorded. The results of this research will shed new light on how different parts of the human brain collaborate to produce the complex behaviors that we take for granted. By understanding these brain signals, we aim to form the foundation for a novel, closed-loop, customizable DBS system.
Principal Investigator: Adam Hebb, MD, FRCSC

Detecting Behavioral Goals from EEG Brain Waves: Parkinson’s disease interferes with starting tasks (such as walking) and switching between tasks. Parkinson’s disease also interferes with switching from one thought to another. This “switching” brain function is located in the frontal lobe, a region of the brain directly connected to areas treated with Deep Brain Stimulation. We strive to understand brain functions involved in this mental flexibility to quickly switch from one task to another. Adults with and without movement disorders such as Parkinson’s disease and Essential Tremor are eligible to participate. While wearing an EEG cap to record brain waves, participants will be asked to perform simple tasks that involve moving a part of the body, speaking, writing, and switching. Research sessions will last 2 hours. Put your mental flexibility to the test!
Principal Investigator: Adam Hebb, MD, FRCSC

Intrepid: Deep Brain Stimulation (DBS) for the Treatment of Parkinson’s Disease: The purpose of this study is to evaluate the safety and effectiveness of Boston Scientific’s Vercise Deep Brain Stimulation (DBS) system in the treatment of patients with advanced levodopa-responsive bilateral Parkinson’s disease (PD) which is not adequately controlled with medication.
eligibility and information
Principal Investigator: Monique Giroux, MD
Sub-Investigators: Sierra Farris, MA, MPAS, CES, PA-C and Adam Hebb, MD, FRCSC

Walking, Balance and Brain Waves in Parkinson’s disease: We are studying how PD affects the brain’s control of walking. Participants will be asked to wear an EEG cap to record brain waves, EMG sensors to record muscle activity, and reflective markers to record body movements while walking.
Principal Investigator: Adam Hebb, MD, FRCSC

Colorado Neurological Insitute